Spondyloarthritis & psoriatic arthritis
Calprotectin (S100A8/A9) is not associated with ultrasound-detected synovitis in a longitudinal study of patients with psoriatic arthritis treated with biological disease-modifying anti-rheumatic drugs
Authors' conclusion
Calprotectin levels were elevated in PsA patients and decreased with treatment but showed no clinically significant correlation with ultrasound-detected synovitis.
Study context
- Population
- Psoriatic arthritis (PsA) patients initiating biological disease-modifying anti-rheumatic drug (bDMARD) therapy, assessed clinically and by US at baseline and after 3, 6, 9 and 12 months
- Participants
- 43 patients
- Exposure
- Plasma calprotectin vs ultrasound-detected synovitis in PsA patients initiating bDMARD therapy
- PsAn = 43
- Outcome
- Association of plasma calprotectin with US-detected synovitis before and during bDMARD treatment
Methodological detailsMean (± SD) age 47.6 (± 12.9) years; 60.5% women; median disease duration 10 years (IQR 4.2-21.9)
- Mean (± SD) age 47.6 (± 12.9) years; 60.5% women; median disease duration 10 years (IQR 4.2-21.9)
Main finding
As reported in the abstract
Correlation between US scores and inflammatory markers
- No clinically relevant correlations between the US scores and inflammatory markers
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline calprotectin, S100A12, IL-6, IL-17A, IL-23 and CXCL10 levelsHigher in PsA than in controls | P < 0.05 |
Change in calprotectin, S100A12 and IL-6 levels during follow-up
- Calprotectin, S100A12 and IL-6 levels decreased during follow-up (p < 0.05)
Joint counts, DAPSA, DAS28-CRP and BASDAI
- Significant reductions
Original publication
Calprotectin (S100A8/A9) is not associated with ultrasound-detected synovitis in a longitudinal study of patients with psoriatic arthritis treated with biological disease-modifying anti-rheumatic drugs. Scand J Rheumatol. Published 13 August 2025. doi:10.
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