Birth Outcomes and Rehospitalizations Among Pregnant Women With Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Offspring
Authors' conclusion
Women with RA or SLE and their infants experienced adverse outcomes, particularly infants of women with SLE. Maternal/infant rehospitalization was more common; most marked in the early months postpartum.
Study context
- Population
- Women with singleton births 1987–2014 in Washington State, and their infants
- Exposure
- Women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) vs unexposed women
- RAn = 1,223
- SLEn = 1,354
- Outcome
- Obstetric/birth outcomes and rehospitalization of mothers and infants, including cause-specific hospitalizations <2 years postpartum
- Follow-up
- <2 years postpartum
Methodological detailspopulation-based, linked vital and hospital discharge records
- Population-based
- Linked vital and hospital discharge records
Main finding
As reported in the abstract
Maternal rehospitalization · <6 months postpartum
Each group vs unexposedAdjusted relative risk (95% CI)
RA
2.22(1.62–3.04)
SLE
2.78(2.15–3.59)
Observational data: associations, not effects.
Further findings
| Outcome | SLE | Unexposed | Estimate | |
|---|---|---|---|---|
| Maternal postpartum rehospitalization for musculoskeletal conditionsRAvs Unexposed | HR 19.1 (95% CI 13.6–26.8) | |||
| Maternal postpartum rehospitalization for musculoskeletal conditionsSLEvs Unexposed | HR 29.8 (95% CI 22.1–40.1) | |||
| Infant malformationsSLEvs Unexposed | 9% | 6% | RR 1.46 (95% CI 1.21–1.75) | |
| Infant mortality · <2 yearsSLEvs Unexposed | RR 2.11 (95% CI 1.21–3.67) | |||
| 0.050.21520Ratio (log scale) |
Infant rehospitalizations · first year of life
- More frequent in infants of women with SLE
Original publication
Birth Outcomes and Rehospitalizations Among Pregnant Women With Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Offspring. Arthritis Care Res (Hoboken). Published 1 March 2023. doi:10.
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