Biopsychosocial determinants and gender disparities in health-related quality of life among rheumatoid arthritis patients: a nationwide multicentre study in China
Authors' conclusion
These findings highlight the biopsychosocial factors affecting HRQoL
Study context
- Population
- Rheumatoid arthritis (RA) patients, nationwide multicentre study in ChinaFemale patients 83.85%
- Exposure
- Female vs male RA patients; determinants of health-related quality of life (HRQoL)
- Outcome
- Determinants of HRQoL (gender-specific, biopsychosocial framework)
Methodological detailsprospective, multicentre, binary logistic regression, stratified analyses
- Prospective
- Multicentre
- Binary logistic regression
- Stratified analyses
Main finding
As reported in the abstract
Determinants of HRQoL (multivariable analysis)
- Better HRQoL linked to urban residence and higher education
- Worse HRQoL related to older age at onset, higher financial burden, GC use, elevated Clinical Disease Activity Index (CDAI), irregular follow up, longer follow-up intervals, comorbidities, anxiety/depressive symptoms, poor sleep satisfaction and fatigue
- Significant interactions among CDAI and financial burden, anxiety/depressive symptoms and sleep satisfaction (stratified analysis)
Observational data: associations, not effects.
Further findings
Age at onset
Disease duration
GC use
| Outcome | Female | Male |
|---|---|---|
| CDAI | 19.00 | 22.00 |
Original publication
Biopsychosocial determinants and gender disparities in health-related quality of life among rheumatoid arthritis patients: a nationwide multicentre study in China. Clin Exp Rheumatol. Published 27 September 2025. doi:10.
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