Data-driven identification of subgroups in early rheumatoid arthritis: mortality and cardiovascular disease in a cohort from western Norway
Authors' conclusion
Four distinct subgroups were identified with different clinical profiles and outcomes.
Study context
- Population
- Patients with incident rheumatoid arthritis (RA) diagnosed 2002–2013 and followed through 2022, western Norwayearly RA
- Participants
- 873 patients
- Exposure
- Data-driven subgroups of early RA vs young-onset subgroup
- Outcome
- Risk of MACE (4p-MACE), death, acute coronary syndrome and stroke by subgroup
Methodological detailslatent class analysis, Cox regression adjusting for age and sex
- Latent class analysis
- Cox regression adjusting for age and sex
Main finding
As reported in the abstract
MACE (4p-MACE)
Each group vs young-onsetHazard ratio (95% CI)
Cardiometabolic
2.14(1.20–3.79)
Elderly-onset
1.89(1.07–3.35)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MortalityCardiometabolicvs Young-onset | 1.79 (1.12–2.87) | |
| 0.20.5125Hazard ratio (log scale) |
Mortality
- Only the cardiometabolic subgroup had increased mortality risk
Original publication
Data-driven identification of subgroups in early rheumatoid arthritis: mortality and cardiovascular disease in a cohort from western Norway. RMD Open. Published 26 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →