Decreased GPR55 expression links B-cell activation and vascular remodelling in atherosclerosis in patients with early rheumatoid arthritis
Authors' conclusion
Reduced GPR55 expression hallmarked B-cells and monocyte subsets in early RA. GPR55 expression was linked to B-cell activation-related pathways, presumably via T-cell independent mechanisms and vascular remodelling.
Study context
- Population
- Treatment-naïve patients with early rheumatoid arthritis (RA), individuals with arthralgia and controls
- Participants
- 63 / 11 / 36
- Comparison
- Treatment-naïve RA vs arthralgia vs controls
- RAn = 63
- Arthralgian = 11
- Controlsn = 36reference
- Outcome
- GPR55 expression in leucocyte populations and its potential role in atherosclerosis
Methodological detailscross-sectional, flow cytometry, in vitro cultures, Atherosclerosis assessed by Doppler US; cytokines by immunoassays; serum proteomics by high-throughput targeted panel
- Cross-sectional
- Flow cytometry
- In vitro cultures
- Atherosclerosis assessed by Doppler US; cytokines by immunoassays; serum proteomics by high-throughput targeted panel
Main finding
As reported in the abstract
GPR55 expression in leucocytes
- Decreased GPR55 expression in B-cells and monocytes in RA
- No differences in arthralgia
- B-cell GPR55 expression unrelated to clinical features, risk factors and atherosclerosis in RA
- GPR55 expression associated with proinflammatory cytokines, immunoglobulin and antibody levels, metabolomic inflammation markers and proteomic signatures of vascular remodelling and B-cell responses in RA; associations dependent on atherosclerosis status
- LPS in vitro decreased B-cell GPR55 expression dose-dependently, overlapping increasing CB86 expression
- Public datasets validated these findings
Original publication
Decreased GPR55 expression links B-cell activation and vascular remodelling in atherosclerosis in patients with early rheumatoid arthritis. RMD Open. Published 26 September 2025. doi:10.
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