Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis
Authors' conclusion
Neutrophils from patients with RA yielded EVs with composition, efficacy, and miR-455-3p content similar to those of healthy volunteers
Study context
- Population
- Male C57BL/6 mice with serum-transfer-induced inflammatory arthritis; neutrophil extracellular vesicles (EVs) from healthy donors and patients with rheumatoid arthritis (RA)
- Comparison
- Intra-articular neutrophil EVs vs vehicle (contralateral joint) in arthritic mice; healthy donor vs RA neutrophil EVs
- EV-treatedn = 8/group
- Contralateral (vehicle)n = 8/groupreference
- Naiven = 4/group
- Arthriticn = 4/group
- Outcome
- Cartilage protection after intra-articular neutrophil EVs in serum-transfer-induced arthritis (collagen-II and collagen-X expression; joint transcriptome)
Methodological detailsexperimental serum-transfer-induced inflammatory arthritis in mice, prophylactic or therapeutic intra-articular protocol, RNA sequencing
- Experimental serum-transfer-induced inflammatory arthritis in mice
- Prophylactic or therapeutic intra-articular protocol
- RNA sequencing
Main finding
As reported in the abstract
Genes differentially expressed (P < 0.05) in arthritic joints
5,231
Differentially expressed genes unique to EV treatment
257
microRNAs in EVs associated with RA
10
Original publication
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. Arthritis Rheumatol. Published 16 August 2024. doi:10.
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