The Risk of Lung Cancer in Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease
Main finding · Lung cancer riskResult — go to the resultAdjusted hazard ratio 1.58 95% CI 1.52–1.64Authors' conclusion
RA was associated with a >50% increased risk of lung cancer, and those with RA-ILD represented a particularly high-risk group with an approximate three-fold increased risk.
Study context
- Population
- Veterans Health Administration, 2000–2019: patients with rheumatoid arthritis (RA) and RA-ILD and matched individuals without RA (mean age 63 years; 88% male)matched cohort
- Exposure
- RA vs matched individuals without RA
- RAn = 72,795
- RA-ILDn = 757
- Non-RAn = 633,937reference
- Outcome
- Incident lung cancer
Methodological detailsmatched (up to 1:10) on age, gender and VA enrollment year, conditional Cox regression, sensitivity analyses
- Matched (up to 1:10) on age, gender and VA enrollment year
- Conditional Cox regression
- Sensitivity analyses
Main finding
Lung cancer risk
Adjusted hazard ratio
1.58
95% CI 1.52–1.64
RAvs Non-RA
aHR 1.58 (95% CI 1.52–1.64)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Lung cancer in never smokers (subgroup)RAvs Non-RA | 1.65 (1.22–2.24) | |
| Lung cancer in incident RA (subgroup)RAvs Non-RA | 1.54 (1.44–1.65) | |
| Lung cancer with and without ILD (prevalent RA-ILD)RA-ILDvs Non-RA | 3.25 (2.13–4.95) | |
| Lung cancer with and without ILD (prevalent RA-ILD)RA without ILDvs Non-RA | 1.57 (1.51–1.64) | |
| Lung cancer, prevalent and incident RA-ILDRA-ILDvs Non-RA | 2.88 (2.45–3.40) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
The Risk of Lung Cancer in Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease. Arthritis Rheumatol. Published 16 August 2024. doi:10.
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