Behçet syndrome in children and adults: discovering similarities and differences by a comparative study
Authors' conclusion
Remarkable differences between juvenile-onset and adult-onset BS, both in terms of gender, familiar predisposition and clinical manifestations have been observed and a different therapeutic approach in the real clinical practice of the two settings emerged.
Study context
- Population
- Italian patients with behçet's syndrome (BS): paediatric and adult databases, Florence
- Participants
- 33 vs 165
- Exposure
- Juvenile-onset vs adult-onset BS
- Paediatricn = 33
- Adultn = 165reference
- Outcome
- Familiar predisposition for BS
Methodological detailstwo clinical databases, single-city (Florence)
- Two clinical databases
- Single-city (Florence)
Main finding
As reported in the abstract
Paediatric
3
events
Adult
1
events
P = 0.015
Observational data: associations, not effects.
Further findings
HLA-B51 positivity
- No difference in prevalence
Meeting revised ICBD and/or ISG criteria at diagnosis
- Comparable in the two cohorts
Muco-cutaneous, ocular, neurological involvement and gastrointestinal symptoms
- No significant difference between cohorts
Articular manifestations
- More common in paediatric cohort
Venous vascular events
- More frequent in adult cohort
Treatment
- Paediatric patients more frequently received no treatment or corticosteroid monotherapy
- Use of traditional and biologic DMARDs significantly higher in adult cohort
Original publication
Behçet syndrome in children and adults: discovering similarities and differences by a comparative study. Rheumatology (Oxford). Published 15 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →