Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state
Authors' conclusion
In new-onset RA, baseline joint-complex power Doppler US associates with week 24 remission. DAS+PDUS- emerges early but, like DAS+PDUS+ and DAS-PDUS-, is a dynamic state, indicating opportunity for therapeutic targeting.
Study context
- Population
- Treatment-naïve, new-onset (early) RA patients from an RCT
- Comparison
- Baseline power Doppler US joint synovitis and/or tenosynovitis categories (PDUS+PDTS+, PDUS+PDTS-, PDUS-PDTS+, PDUS-PDTS-)
- Primary endpoint
- Remission
- Follow-up
- Week 24
Methodological detailslongitudinal, Bayesian logistic regression
- Longitudinal
- Bayesian logistic regression
Primary result
As reported in the abstract
Week 24 remission
Baseline PDUS+PDTS+ associated with week 24 remission, posterior estimate (credible interval 0.16-2.65)
1.41
Further findings
Concordance/discordance states of clinical disease activity and PDUS
- DAS+PDUS+ at baseline
- 68%
- DAS+PDUS- at baseline
- 32%
- Early transition DAS+PDUS+ to DAS+PDUS- at week 12
- 32%
- DAS+PDUS- at week 24
- 43%
- Baseline DAS+PDUS- remaining DAS+PDUS- through week 48
- 41%
Original publication
Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state. Rheumatology (Oxford). Published 17 February 2025. doi:10.
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