Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis
Authors' conclusion
Autoantibody reactivity in JIA primarily targets chromatin, but the epitopes targeted are likely either posttranslationally modified or multimolecule epitopes, such as dsDNA-nucleosome complexes, rather than epitopes on individual native proteins or purified dsDNA.
Study context
- Population
- Untreated children with active juvenile idiopathic arthritis (JIA), children with unspecified arthritis and age- and sex-matched healthy children
- Participants
- 110 / 14 / 151
- Exposure
- Untreated active JIA vs age- and sex-matched healthy children
- JIAn = 110
- Unspecified arthritisn = 14
- Healthy controlsn = 151reference
- Outcome
- Homogeneous nuclear ANA staining (reactivity toward chromatin)
Methodological detailsage- and sex-matched healthy controls, HuProt proteome microarray
- Age- and sex-matched healthy controls
- HuProt proteome microarray
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | JIA | P value |
|---|---|---|
| Antibodies against dsDNA-nucleosome complexesJIA vs Healthy controls | 20% | P < 0.0001 |
Antibodies to specific nuclear antigens or other connective tissue disease autoantigens
- No antibody reactivity detected
Proteome microarray (5 ANA-positive JIA, 4 ANA-negative healthy controls)
- Core histone H2A variant H2AFY (part of the nucleosome) the most widely recognised human protein by JIA autoantibodies
Original publication
Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis. Arthritis Rheumatol. Published 21 September 2025. doi:10.
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