Systemic sclerosis & Raynaud's
Autoantibody associations in patients with early diffuse cutaneous systemic sclerosis: the prospective registry of early systemic sclerosis
Authors' conclusion
Autoantibody-specific differences in organ involvement were evident early. The double-negative group uniquely showed improvement in lung function over time.
Study context
- Population
- Adults with diffuse cutaneous SSc (dcSSc) ≤2 years from the first non-Raynaud's phenomenon symptom meeting 2013 ACR/EULAR classification criteria for SSc, 12 U.S. academic centers (Prospective Registry of Early Systemic Sclerosis (PRESS)); dual-positive excluded303 enrolled
- Participants
- 233 adults
- Exposure
- ARA+ vs ATA+ vs double-negative autoantibody groups
- ARA+n = 108
- ATA+n = 68
- Double-negativen = 57
- Outcome
- Organ involvement by autoantibody group
Methodological detailsmulticentre, registry, Evaluated every 6 months
- Multicentre
- Registry
- Evaluated every 6 months
Further findings
| Outcome | ARA+ | ATA+ | Double-negative | P value |
|---|---|---|---|---|
| Baseline FVC% predictedATA+ vs ARA+ | 86.0% | 76.0% | — not stated in the abstract | P = 0.0011 |
| Prevalence of ILDATA+ vs ARA+ | 44.3% | 69.6% | — not stated in the abstract | P = 0.0029 |
| Baseline mRSSARA+ vs ATA+ | 25.0 | 17.9 | — not stated in the abstract | P < 0.0001 |
| Prevalence of SRCARA+ vs ATA+ | 14.4% | 0.0% | — not stated in the abstract | P = 0.0024 |
| Change in FVC% predicted over time | — not stated in the abstract | — not stated in the abstract | +1.39% per year |
— not stated in the abstract
- Change in FVC% predicted over time — Only the double-negative group had improvement in FVC% predicted over time
- p = 0.03
Original publication
Autoantibody associations in patients with early diffuse cutaneous systemic sclerosis: the prospective registry of early systemic sclerosis. Semin Arthritis Rheum. Published 26 June 2026. doi:10.
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