Lupus & antiphospholipid syndrome

Attribution of neuropsychiatric symptoms and prioritization of evidence in the diagnosis of neuropsychiatric lupus: mixed methods analysis of patient and clinician perspectives from the international INSPIRE study

Rheumatology (Oxford)Published Mixed methods study

Authors' conclusion

NPSLE diagnostic tests and clinician assessments have numerous limitations, particularly in detecting diffuse neuropsychiatric symptoms that can be directly attributable and benefit from immunosuppression.

Study context

Population
Clinicians and SLE patients in the international INSPIRE study
Comparison
Patient vs clinician perspectives on attribution of neuropsychiatric symptoms in SLE
Outcome
Attribution of neuropsychiatric symptoms and prioritization of evidence in NPSLE diagnosis
Methodological detailsthematic and comparative analyses, surveys and interviews, international
  • Thematic and comparative analyses
  • Surveys and interviews
  • International

Main finding

As reported in the abstract

Patients reporting never/rarely having been asked if their SLE was flaring

46%

Patients reporting self-assessment of disease activity never/rarely concordant with their clinicians

24%

Original publication

Attribution of neuropsychiatric symptoms and prioritization of evidence in the diagnosis of neuropsychiatric lupus: mixed methods analysis of patient and clinician perspectives from the international INSPIRE study. Rheumatology (Oxford). Published 18 December 2023. doi:10.1093/rheumatology/kead685

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