Lupus & antiphospholipid syndrome
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis
Authors' conclusion
We found genetic evidence to support a causal link between 25-hydroxycholecalciferol concentrations and psoriasis and systemic lupus erythematosus.
Study context
- Population
- UK Biobank participants; autoimmune disease defined using ICD code and/or self-report23,089 with ≥1 autoimmune disease
- Participants
- 332,984 participants
- Comparison
- Genetically-predicted vitamin D
- Autoimmunityn = 12,774
- Autoinflammationn = 11,164
- Outcome
- Composite and individual autoimmune diseases
Methodological detailsweighted genetic score, ratio method, non-linear analysis across five quantiles of 25-hydroxycholecalciferol
- Weighted genetic score
- Ratio method
- Non-linear analysis across five quantiles of 25-hydroxycholecalciferol
Main finding
As reported in the abstract
Risk of autoimmune disease by mechanistic subgroup, per 10 ng/ml increase in 25-hydroxycholecalciferol
Odds ratio (95% CI)P value
Autoinflammationper 10 ng/ml increase in 25-hydroxycholecalciferol
0.95(0.91–0.99)
P = 0.03Autoimmunity
0.99(0.95–1.03)
P = 0.64Per 10 ng/ml increase in 25-hydroxycholecalciferol, as printed
Further findings
Psoriasis (individual disease)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Genetically-predicted vitamin DResults replicated using data from independent studies | 0.91 (0.85–0.97) | P = 0.005 | |
| 0.512Odds ratio (log scale) |
SLE (individual disease)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Genetically-predicted vitamin DSuggestive association · results replicated using data from independent studies | 0.84 (0.69–1.02) | P = 0.08 | |
| 0.512Odds ratio (log scale) |
Non-linear relationship between vitamin D and any outcome
- No evidence for a plausible non-linear relationship
Original publication
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. Published 30 June 2023. doi:10.
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