Associations between ultra-distal forearm bone mineral density and incident fracture in women
Main finding · Any fractureResult — go to the resultHazard ratio 1.26 95% CI 1.15–1.39Authors' conclusion
Ultra-distal forearm BMD may aid risk assessments for any distal radius fractures.
Study context
- Population
- Geelong Osteoporosis Study women aged 40–90 years with bone mineral density (BMD) measured (Lunar DPX-L)
- Participants
- 1,026 women14,270 person-years
- Exposure
- Ultra-distal forearm BMD and incident fracture
- Outcome
- Incident radiologically verified low-trauma fracture (any fracture and distal radius fracture)
Methodological detailslongitudinal, Cox proportional hazard models, areas under receiver operating characteristics (AUROC) analysis
- Longitudinal
- Cox proportional hazard models
- AUROC analysis
Main finding
Any fracture
Hazard ratio
1.26
95% CI 1.15–1.39
Continuous BMDUDforearmvs Normal
HR 1.26 (95% CI 1.15–1.39)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Distal radius fractureContinuous BMDUDforearmvs NormalAdjusted models | 1.59 (1.38–1.83) | |
| Any fracture, categorical BMDUDforearmOsteoporosisvs NormalAdjusted models | 2.12 (1.50–2.98) | |
| Distal radius fracture, categorical BMDUDforearmOsteopeniavs Normal | 4.31 (2.59–7.15) | |
| Distal radius fracture, categorical BMDUDforearmOsteoporosisvs Normal | 4.81 (2.70–8.58) | |
| 0.10.31310Hazard ratio (log scale) |
AUROC, any fracture
- AUROCs for continuous BMDUDforearm, BMD33%forearm, BMDhip, BMDspine and FRAX without BMD similar
- P > 0.05
- Categorical BMD similar at all sites but lower for FRAX
- P < 0.05
AUROC, distal radius fracture
- AUROC for BMDUDforearm higher than other sites and FRAX (continuous and categorical)
- P < 0.05
Original publication
Associations between ultra-distal forearm bone mineral density and incident fracture in women. Osteoporos Int. Published 6 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →