Proton pump inhibitors, bone and phosphocalcic metabolism
Authors' conclusion
Despite growing evidence of PPI-related risks, further research is essential to better understand the complex mechanisms, as most data are from observational studies and do not establish a causal relationship.
Study context
- Outcome
- Effects of proton pump inhibitors (PPIs) on bone health and phosphocalcic and magnesium metabolism
Pooled result
As reported in the abstract
- Effect of PPI use on BMD: mixed results
- Observational studies: increased risk of fractures, particularly vertebral fractures, with PPI use
- Recent meta-analyses: association between PPI use and hip fractures, dose-dependent
- PPI-induced hypomagnesemia (PPIH) well established; hypocalcemia secondary to severe hypomagnesemia described
- Most data are from observational studies and do not establish a causal relationship
Original publication
Proton pump inhibitors, bone and phosphocalcic metabolism. Joint Bone Spine. Published 6 March 2024. doi:10.
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