Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study, Norway
Authors' conclusion
Participants with rheumatoid arthritis had a 40% higher risk of fracture than participants without the disease. A similar fracture risk was observed for conventional synthetic DMARD use, whereas there was weak evidence that the use of biological DMARDs may be associated with a somewhat lower fracture risk.
Study context
- Population
- Participants in the population-based Nord-Trndelag Health Study (HUNT), Norway9,670 fractures
- Participants
- 92,285 participants
- Exposure
- RA, overall and by DMARD treatment, vs participants without RA
- RAn = 605
- Outcome
- First major osteoporotic fracture
Methodological detailspopulation-based, Cox regression
- Population-based
- Cox regression
Main finding
As reported in the abstract
Major osteoporotic fracture
RA
88
events
Each group vs without RAHazard ratio (95% CI)
RA
1.41(1.13–1.74)
csDMARD users
1.44(1.15–1.81)
bDMARD users
1.19(0.64–2.21)
Observational data: associations, not effects.
Original publication
Rheumatoid arthritis, disease-modifying antirheumatic drugs and risk of major osteoporotic fracture: prospective data from the HUNT Study, Norway. RMD Open. Published 20 February 2024. doi:10.
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