Spondyloarthritis & psoriatic arthritis
Associations between family history of psoriatic disease and clinical characteristics on patients with psoriatic arthritis: a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR II)
Authors' conclusion
The findings from the present study revealed that family history of psoriasis and/or PsA had greater effects on disease phenotypes of PsA, especially nail disease and enthesitis.
Study context
- Population
- Chinese patients with PsA in the CREPAR registry, December 2018–June 2021
- Participants
- 1,074 patients
- Exposure
- PsA with vs without a family history of psoriasis and/or PsA
- Family historyn = 313
- Outcome
- Clinical characteristics associated with family history of psoriatic disease
Methodological detailsnationwide registry (CREPAR), multivariable logistic regression
- Nationwide registry (CREPAR)
- Multivariable logistic regression
Main finding
As reported in the abstract
Clinical characteristics associated with positive family history (adjusted logistic regression)
Family history
29.1%
313
Each group vs no family historyEstimate (95% CI)P value
Family history
OR (female sex) 1.514(1.088–2.108)
P = 0.014Family history
OR (age at psoriasis onset) 0.971(0.955–0.988)
P = 0.001Family history
OR (HLA-B27 positivity) 1.625(1.089–2.426)
P = 0.018Family history
OR (nail involvement) 1.424(1.007–2.013)
P = 0.046Family history
OR (enthesitis) 1.393(1.005–1.930)
P = 0.046Family history
OR (hyperlipidaemia) 2.550(1.506–4.317)
P = 0.001Observational data: associations, not effects.
Further findings
Unadjusted comparison vs no family history
- Family history: earlier age of onset of psoriasis and PsA, more enthesitis and nail involvement, higher human leukocyte antigen-B27 (HLA-B27) positivity, lower DAS28-ESR, more hyperlipidaemia, less hypertension and diabetes
Original publication
Associations between family history of psoriatic disease and clinical characteristics on patients with psoriatic arthritis: a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR II). Clin Exp Rheumatol. Published 27 June 2022. doi:10.
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