Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents
Authors' conclusion
The CTLA-4 exon 1 + 49A/G polymorphism may confer susceptibility to Juvenile-onset SLE. Moreover, CTLA-4 G/G genotype and G allele at exon 1 + 49 may constitute independent risk factors for development of lupus nephritis in Egyptian children and adolescents.
Study context
- Population
- Egyptian children and adolescents with Juvenile-onset SLE and healthy controls
- Participants
- 260 vs 260
- Comparison
- JSLE patients vs healthy controls
- JSLEn = 260
- Healthy controlsn = 260reference
- Outcome
- CTLA-4 exon 1 + 49A/G (rs231775) SNP as a genetic marker for susceptibility to JSLE
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
JSLE vs Healthy controlsOdds ratio (95% CI)P value
G/G genotype
4.2(2.4–7.3)
P < 0.01G allele
1.7(1.3–2.2)
P < 0.01Observational data: associations, not effects.
Further findings
Lupus nephritis risk by CTLA-4 G/G genotype and G allele
| OR (95% CI) | P value | ||
|---|---|---|---|
| G/G genotype | 5.09 (1.7–13.9) | P = 0.0001 | |
| G-allele | 2.4 (1.5–3.78) | P = 0.004 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents. Lupus. Published 5 January 2026. doi:10.
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