Association between Mycobacterium tuberculosis infection and the risk of inflammatory arthritides
Main finding · Overall risk of IAResult — go to the resultHazard ratio 1.71 95% CI 1.51–1.93Authors' conclusion
The increased overall risk of developing IA after tuberculosis corroborates the hypothesis that tuberculosis can trigger dysregulated immunity.
Study context
- Population
- South Korean National Claims database, 2010 to 2021mean follow-up 7.5 years
- Participants
- 408,685 vs 159,675
- Exposure
- Incident tuberculosis vs appendectomy controls
- Tuberculosisn = 408,685
- Controlsn = 159,675reference
- Outcome
- Onset of IA (SPRA, AS and PsA) after tuberculosis
Methodological detailsnationwide claims database, multivariable Cox regression, sensitivity analysis with stabilised inverse probability of treatment weighting (sIPTW)
- Nationwide claims database
- Multivariable Cox regression
- Sensitivity analysis with sIPTW
Main finding
Overall risk of IA
Hazard ratio
1.71
95% CI 1.51–1.93
Tuberculosisvs Controls
HR 1.71 (95% CI 1.51–1.93)
As reported in the abstract
- Diagnosed with inflammatory arthritides (IA) (total)
- 1,957 (0.3%)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| IA subgroups (adjusted)Tuberculosisvs ControlsSPRA cases 1,397 | HR (SPRA) 1.72 (95% CI 1.49–2.00) | |
| IA subgroups (adjusted)Tuberculosisvs ControlsAS cases 481 | HR (AS) 1.64 (95% CI 1.30–2.06) | |
| IA subgroups (adjusted)Tuberculosisvs ControlsPsA cases 79 | HR (PsA) 2.59 (95% CI 1.32–5.07) | |
| 0.20.5125Ratio (log scale) |
IA subgroups (adjusted)
- Replicated in the sIPTW sensitivity analysis
Original publication
Association between Mycobacterium tuberculosis infection and the risk of inflammatory arthritides. Clin Exp Rheumatol. Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →