Temporal trends in overall infection incidence in patients with inflammatory arthritides treated with tumour necrosis factor inhibitors: a nationwide cohort study
Main finding · SI, last vs first period (TNFi-treated)Result — go to the resultIncidence rate ratio 0.48 CI 0.25–0.94Authors' conclusion
The study found that the IRR of serious infections associated with TNFi in patients with inflammatory arthritides has decreased over the years.
Study context
- Population
- Adult biologic-naive patients with RA, PsA and SpA initiating a tumour necrosis factor inhibitors (TNFi), ICEBIO registry; observed 2 years before and after TNFi initiation
- Participants
- 1,387 vs 6,936
- Exposure
- TNFi-treated patients with inflammatory arthritides, last vs first period, and general population comparators
- TNFin = 1,387
- Comparatorsn = 6,936reference
- Outcome
- Temporal trends in incidence rate (IR) (per 1000 patient-years) and IRR of serious infections and antimicrobial prescriptions across four-year periods
Methodological detailsnationwide, matched on age, sex and calendar time to five general population comparators, ICEBIO registry, four-year periods
- Nationwide
- Matched on age, sex and calendar time to five general population comparators
- ICEBIO registry
- Four-year periods
Main finding
SI, last vs first period (TNFi-treated)
Incidence rate ratio
0.48
CI 0.25–0.94
P = 0.03
TNFi, last periodvs TNFi, first period
IRR 0.48 (CI 0.25–0.94); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (CI) | |
|---|---|---|
| Antimicrobial prescriptions, between-period IRR (last vs first period)Between-period IRR | 1.05 (0.93–1.2) | |
| 0.512Incidence rate ratio (log scale) |
Comparators: Serious infections (SI) and antimicrobial prescriptions, between-period IRR
| IRR (CI) | ||
|---|---|---|
| ComparatorsAntimicrobial prescriptions; between-period IRR | 1.2 (1.1–1.3) | |
| 0.512Incidence rate ratio (log scale) |
- IRR for comparators was stable for SI
Original publication
Temporal trends in overall infection incidence in patients with inflammatory arthritides treated with tumour necrosis factor inhibitors: a nationwide cohort study. Clin Exp Rheumatol. Published 10 December 2024. doi:10.
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