Association Between HLA–DPB1 and Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Children
Main finding · Association of HLA-DPB1*04:01 allele with pediatric AAVResult — go to the resultOdds ratio 3.5Authors' conclusion
The HLA-DPB1 locus showed an association with pediatric AAV, as similarly shown previously in adult AAV.
Study context
- Population
- Pediatric AAV patients of European ancestry
- Participants
- 63 vs 315
- Comparison
- Pediatric AAV cases vs population-matched controls
- AAV casesn = 63
- Controlsn = 315reference
- Outcome
- Genetic association with pediatric AAV (genome-wide)
Methodological detailscase-control, population-matched controls
- Case-control
- Population-matched controls
Main finding
As reported in the abstract
Association of HLA-DPB1*04:01 allele with pediatric AAV
Odds ratio
3.5
P = 1.5 × 10-8
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| HLA-DPB1*04:01 in follow-up adult AAV cohort (most highly associated HLA allele, not significant)Not significant | 0.4 | P = 2.6 × 10-4 |
Pathway enrichment
- T cell receptor and interferon signaling pathways enriched in pediatric AAV cohort
Original publication
Association Between HLA–DPB1 and Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Children. Arthritis Rheumatol. Published 30 March 2023. doi:10.
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