Association between beverage consumption and risk of rheumatoid arthritis: a prospective study from the French E3N Cohort
Authors' conclusion
In a large cohort of women, tea, alcohol and sugar-sweetened soft drinks consumption was not associated with RA risk, whereas consumption of coffee (especially caffeinated coffee), and artificially sweetened soft drinks was associated with higher RA risk, particularly among never-smokers.
Study context
- Population
- Women of the French E3N prospective cohort (98,995 women since 1990)481 incident RA cases
- Participants
- 62,631 women
- Exposure
- Consumption of coffee, tea, alcohol and soft drinks and risk of RA
- Outcome
- Incident RA
Methodological detailsCox proportional hazards model, validated food-frequency questionnaire
- Cox proportional hazards model
- Validated food-frequency questionnaire
Main finding
As reported in the abstract
Incident RA by beverage consumption
Hazard ratio (95% CI)P value
≥4 cups/day coffeevs ≤1cup/day coffeelinear association
1.24(0.94–1.64)
P = 0.04for trendArtificially sweetened soft drink consumersvs Non-consumers of artificially sweetened soft drinksparticularly in never-smokers
1.66(1.12–2.45)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| RA in ever-smokers, liquor intake (subgroup)1-3 glasses/week liquorvs Liquor non-consumers | 0.63 (0.43–0.91) | |
| 0.512Hazard ratio (log scale) |
RA in ever-smokers, liquor intake (subgroup)
- Moderate wine consumption associated with reduced risk of seropositive RA in ever-smokers
Original publication
Association between beverage consumption and risk of rheumatoid arthritis: a prospective study from the French E3N Cohort. Rheumatology (Oxford). Published 30 September 2022. doi:10.
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