Lupus & antiphospholipid syndrome
Association Between 25‐hydroxyvitamin D Levels and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus
Authors' conclusion
Our study is not able to prove causation, but the results strongly suggest an association of 25(OH)D at both lower and higher levels with adverse pregnancy outcomes.
Study context
- Population
- Pregnant patients with systemic lupus erythematosus (SLE) in the Hopkins Lupus Cohort
- Exposure
- Subgroups defined by average 25D levels
- Outcome
- Adverse pregnancy outcomes:
- Miscarriage
- Preterm delivery
- Small for gestational age
Methodological detailstime-to-event analysis, time-varying 25(OH)D levels, adjusted for SLE disease activity
- Time-to-event analysis
- Time-varying 25(OH)D levels
- Adjusted for SLE disease activity
Main finding
As reported in the abstract
Adverse pregnancy outcomes by average 25(OH)D level subgroups
- Significantly different risk of miscarriage across 25(OH)D subgroups
- P = 0.0045
- Significantly different risk of preterm delivery across 25(OH)D subgroups
- P = 0.0007
- Significantly different risk of composite of all three adverse pregnancy outcomes across 25(OH)D subgroups
- P = 0.011
Observational data: associations, not effects.
Further findings
Premature delivery with low vitamin D in the second trimester
- Pregnant patients with low vitamin D levels who had a premature delivery
- 9 of 10
Time to miscarriage or preterm delivery (time-to-event model)
- Same U-shaped association after adjustment for SLE disease activity; increased risk at highest vitamin D levels not statistically significant
- BMI did not appear to be a confounding factor
- Adjusted for SLE disease activity
Original publication
Association Between 25‐hydroxyvitamin D Levels and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →