Lupus & antiphospholipid syndrome
Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis
Authors' conclusion
Urinary ALCAM is reflective of changes in LN and may be predictive of response status.
Study context
- Population
- Biopsy-proven LN subjects; serum and urine sampled at weeks 0, 12, 26 and 52 across multiple study sites
- Participants
- 122 subjects
- Exposure
- Urinary activated leucocyte cell adhesion molecule (ALCAM) vs urinary CD6 as predictors of LN
- Outcome
- Urinary ALCAM and CD6 as predictors of LN progression or disease resolution
- Follow-up
- 1 year
Methodological detailsmulticentre, biomarker study, cross-sectional and longitudinal analyses
- Multicentre
- Biomarker study
- Cross-sectional and longitudinal analyses
Main finding
As reported in the abstract
Prediction of LN (ROC analysis)
| Group | AUC |
|---|---|
| Urinary ALCAM | 0.97 |
| Urinary CD6 | 0.71 |
AUC
Urinary ALCAM0.97
Urinary CD60.71
Observational data: associations, not effects.
Further findings
Baseline cross-sectional correlations of urinary ALCAM
- Significant correlation with urine protein creatinine ratio, renal SLEDAI and Physician Global Assessment (PGA)
- Negative correlation with serum C3 and C4
Original publication
Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis. Rheumatology (Oxford). Published 15 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →