Assessment of colchicine adherence and influencing factors in paediatric familial Mediterranean fever
Authors' conclusion
Colchicine non-adherence is frequent in paediatric FMF and largely unrelated to patient factors.
Study context
- Population
- Paediatric familial Mediterranean fever (FMF) patients (1–18 years old)mean age 11.8 ± 3.8 years
- Participants
- 324 patients
- Exposure
- Good vs poor colchicine adherence
- Good adherencen = 88
- Poor adherencen = 236
- Outcome
- Colchicine adherence measured via MASIF
Main finding
As reported in the abstract
Colchicine adherence (MASIF)
Observational data: associations, not effects.
Further findings
School absenteeism
P < 0.001
Adherence vs sex, age group, age at diagnosis, disease severity, family history, colchicine intolerance/resistance, biologic use
- Adherence not significantly associated with sex, age group, age at diagnosis, disease severity, family history, colchicine intolerance/resistance, or biologic use
Erysipelas-like erythema at diagnosis and adherence
- Erysipelas-like erythema present at diagnosis
- 28 (8.6%)
- Correlated with better adherence
- P = 0.016
Self-reported regular colchicine use vs MASIF
- Self-reported regular colchicine use
- 142 (43.8%)
- Poor adherence by MASIF among self-reported regular users
- 101 (71.1%)
Original publication
Assessment of colchicine adherence and influencing factors in paediatric familial Mediterranean fever. Scand J Rheumatol. Published 16 February 2026. doi:10.
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