Lupus & antiphospholipid syndrome
Application of lupus comprehensive disease control in newly diagnosed systemic lupus erythematosus patients: results from the Italian multicentre Early Lupus Project inception cohort
Authors' conclusion
CDC in early onset SLE is not uncommon. Indeed, one-third of patients achieved LupusCDC-GCon in at least one evaluation. More severe disease, characterised by active renal and neuropsychiatric manifestations represented a risk factor for failure to achieve LupusCDC.
Study context
- Population
- Newly diagnosed Systemic Lupus Erythematosus (SLE) patients, Italian multicentre Early Lupus Project inception cohort205F
- Participants
- 239 participants
- Outcome
- Incidence of LupusCDC (remission without progression of chronic damage), GCon (ECLAM=0, PDN ≤5 mg/day) and GCoff
- Follow-up
- 36 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
LupusCDC achieved in at least one evaluation
LupusCDC-GCon
33.08%
LupusCDC-GCoff
12.03%
Observational data: associations, not effects.
Further findings
Factors associated with failure to achieve LupusCDC-GCon (univariate; confirmed by multivariate analysis)
- Musculoskeletal manifestations
- P < 0.001
- Renal activity
- P = 0.01
- Neuropsychiatric activity
- P < 0.001
- Association confirmed by the multivariate analysis
Original publication
Application of lupus comprehensive disease control in newly diagnosed systemic lupus erythematosus patients: results from the Italian multicentre Early Lupus Project inception cohort. Clin Exp Rheumatol. Published 19 November 2024. doi:10.
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