Lupus & antiphospholipid syndrome
Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients
Authors' conclusion
Four clinical indicators of ESR, mucosal ulcer, proteinuria, and hematuria were independent risk factors for LN in SLE patients. The predictive power of the Nomogram model based on LASSO-logistic regression was acceptable
Study context
- Population
- Systemic Lupus Erythematosus (SLE) patients, Meishan People's Hospital, July 2012 to December 2021
- Participants
- 555 patients
- Exposure
- SLE with lupus nephritis (LN) vs SLE without LN
- LNn = 303
- Without LNn = 252reference
- Outcome
- Risk factors for LN in SLE patients and a nomogram prediction model
Methodological detailssingle-centre, LASSO-logistic regression, nomogram prediction model
- Single-centre
- LASSO-logistic regression
- Nomogram prediction model
Main finding
As reported in the abstract
Independent risk factors for LN
Decision curve analysis: net clinical benefit at threshold probability
0.12-0.54
Observational data: associations, not effects.
Original publication
Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients. Lupus. Published 22 July 2023. doi:10.
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