Altered Risk of Incident Gout According to Changes in Metabolic Syndrome Status: A Nationwide, Population‐Based Cohort Study of 1.29 Million Young Men
Authors' conclusion
Changes in the status and clinical characteristics of metabolic syndrome were associated with altered risk of incident gout.
Study context
- Population
- Men aged 20–39 years who participated in serial health check-ups18,473 incident gout
- Participants
- 1,293,166 men
- Exposure
- Changes in metabolic syndrome status across 3 health check-ups vs no metabolic syndrome at any check-up
- Outcome
- Incident gout (claims database diagnostic code for gout)
Methodological detailsserial health check-ups, Cox proportional hazards models
- Serial health check-ups
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident gout
Each group vs no metabolic syndromeAdjusted hazard ratio (95% CI)
Chronic metabolic syndrome
3.82(3.67–3.98)
Development of metabolic syndrome
2.31(2.20–2.43)
Recovery from metabolic syndrome
0.52(0.49–0.56)
- Incidence rate of gout, per 1,000 person-years
- 3.36
Observational data: associations, not effects.
Further findings
Incident gout by change in elevated triglycerides
| aHR (95% CI) | ||
|---|---|---|
| Development of elevated triglycerides | 1.74 (1.66–1.81) | |
| Recovery from elevated triglycerides | 0.56 (0.54–0.59) | |
| 0.512Adjusted hazard ratio (log scale) |
Incident gout by change in abdominal obesity
| aHR (95% CI) | ||
|---|---|---|
| Development of abdominal obesity | 1.94 (1.85–2.03) | |
| Recovery from abdominal obesity | 0.69 (0.64–0.74) | |
| 0.512Adjusted hazard ratio (log scale) |
Incident gout by age and weight subgroups
- Associations more pronounced in subjects ages 20-29 years vs 30-39 years, and in underweight or normal-weight subjects
Original publication
Altered Risk of Incident Gout According to Changes in Metabolic Syndrome Status: A Nationwide, Population‐Based Cohort Study of 1.29 Million Young Men. Arthritis Rheumatol. Published 25 March 2023. doi:10.
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