Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout
Authors' conclusion
Genetic risk variants for gout also harbor risk for earlier age at gout onset and tophaceous disease in European and Polynesian men.
Study context
- Population
- European, East Polynesian and West Polynesian men and women with gout7 European, 2 East Polynesian and 1 West Polynesian gout cohorts
- Participants
- 4,016 / 682 / 490
- Comparison
- Gout polygenic risk score and age at gout onset and tophaceous disease
- Europeann = 4,016
- East Polynesiann = 682
- West Polynesiann = 490
- Outcome
- Age at gout onset and tophaceous disease, per unit PRS
Methodological detailssex-stratified regression models, 19-variant gout polygenic risk score (PRS), multiple cohorts (7 European, 2 East Polynesian, 1 West Polynesian)
- Sex-stratified regression models
- 19-variant gout PRS
- Multiple cohorts (7 European, 2 East Polynesian, 1 West Polynesian)
Main finding
As reported in the abstract
Age at gout onset (β in years per unit PRS), men
β
−3.61 years per unit PRS
95% CI −4.32 to −2.90
European men
β
−6.35 years per unit PRS
95% CI −8.91 to −3.80
East Polynesian men
β
−3.51 years per unit PRS
95% CI −5.46 to −1.57
West Polynesian men
Further findings
Age at gout onset (β in years per unit PRS), women
| β (years per unit PRS) (95% CI) | |
|---|---|
| European women | 0.07 (−2.32 to 2.45) |
| East Polynesian women | 0.20 (−7.21 to 7.62) |
| West Polynesian women | −3.33 (−9.28 to 2.62) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Tophaceous disease (OR per unit PRS), menEuropean men | 1.15 (1.00–1.31) | |
| Tophaceous disease (OR per unit PRS), menEast Polynesian men | 2.60 (1.66–4.06) | |
| Tophaceous disease (OR per unit PRS), menWest Polynesian men | 1.53 (1.07–2.19) | |
| Tophaceous disease (OR per unit PRS), womenEuropean women | 0.68 (0.42–1.10) | |
| Tophaceous disease (OR per unit PRS), womenEast Polynesian women | 1.45 (0.39–5.36) | |
| 0.20.5125Odds ratio (log scale) |
Age at gout onset, PRS without ABCG2 variants, men
| β (95% CI) | |
|---|---|
| European menSensitivity analysis | −2.42 (−3.37 to −1.46) |
| East Polynesian menSensitivity analysis | −6.80 (−10.06 to −3.55) |
| West Polynesian menSensitivity analysis | −1.79 (−4.74 to 1.16) |
Original publication
Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout. Arthritis Rheumatol. Published 25 March 2023. doi:10.
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