Age of onset of rheumatoid arthritis and radiographic changes
Authors' conclusion
The odds of incident joint erosion and change in the mTSS were increased among patients with later RA onset.
Study context
- Population
- Patients diagnosed with rheumatoid arthritis (RA) within 2 years of enrollment in a large single-center RA registryof 1,581 registry participants
- Participants
- 284 patients
- Exposure
- Middle- and late-onset vs young-onset RA
- Outcome
- Incident joint erosion (erosion score >0) and adjusted change in Modified total Sharp scores (mTSS)
- Follow-up
- 5-year follow-up
Methodological detailssingle-centre registry
- Single-centre registry
Main finding
As reported in the abstract
Incident joint erosion
Each group vs young-onsetAdjusted odds ratio (95 % CI)
Middle-onset
4.0(2.2–7.5)
Late-onset
8.2(3.6–19.2)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted change (95 % CI) | |
|---|---|---|
| Adjusted change in mTSS · 5-year follow-upMiddle-onsetvs Young-onset | 2.8 (0.20–5.4) | |
| Adjusted change in mTSS · 5-year follow-upLate-onsetvs Young-onset | 1.9 (−0.26 - 4.1) | |
| −50510Difference (linear scale) |
Mean
| Outcome | Young-onset | Middle-onset | Late-onset |
|---|---|---|---|
| mTSS | 0.54 | 3.12 | 4.77 |
Original publication
Age of onset of rheumatoid arthritis and radiographic changes. Semin Arthritis Rheum. Published 28 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →