Systemic sclerosis & Raynaud's
ADAMTS13 and insulin resistance in systemic sclerosis patients
Authors' conclusion
ADAMTS13 serum levels are decreased in patients with SSc. Additionally, a positive correlation exists between ADAMTS13 levels and insulin resistance in SSc.
Study context
- Population
- Individuals diagnosed with sclerosis-scleroderma (SSc) and healthy age- and sex-matched controls
- Participants
- 81 vs 76
- Exposure
- SSc vs healthy controls
- SScn = 81
- Healthy controlsn = 76reference
- Outcome
- Serum ADAMTS13 levels in SSc vs healthy controls
Methodological detailsage- and sex-matched controls, multivariable linear regression
- Age- and sex-matched controls
- Multivariable linear regression
Main finding
As reported in the abstract
Serum ADAMTS13 levels
- Serum ADAMTS13 levels significantly decreased in SSc vs healthy controls after multivariable analysis
Observational data: associations, not effects.
Further findings
ADAMTS13 and CRP
- Significant negative correlation between CRP and circulating ADAMTS13 levels
ADAMTS13 and disease characteristics
- Pulmonary, articular and cutaneous manifestations not significantly associated with ADAMTS13 values
ADAMTS13 and insulin resistance
- Significant positive association of ADAMTS13 with insulin resistance indices in SSc; not observed in controls
Original publication
ADAMTS13 and insulin resistance in systemic sclerosis patients. Clin Exp Rheumatol. Published 7 November 2024. doi:10.
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