Fibromyalgia & musculoskeletal pain
Acute activation of rat dorsal root ganglion neurons and their satellite glial cells by the serum of patients suffering from fibromyalgia
Authors' conclusion
Serum of patients suffering from fibromyalgia induces more intense and widespread acute stimulation on ATP-insensitive SGCs.
Study context
- Population
- Wistar rat dorsal root ganglia (DRG) neuron and satellite glial cell primary cultures exposed to sera of women with FM and healthy women1,477 DRG neurons studied
- Participants
- 6 vs 6
- Comparison
- Serum of women with FM vs serum of healthy women
- FMn = 6
- Healthy controlsn = 6reference
- Outcome
- Acute stimulation of DRG neurons and/or their SGCs (intracellular calcium, Fluo-4)
Methodological detailsin vitro, rat DRG neuron and SGC primary cultures, Fluo-4 calcium imaging
- In vitro
- Rat DRG neuron and SGC primary cultures
- Fluo-4 calcium imaging
Main finding
As reported in the abstract
Proportion of ATP-insensitive SGCs stimulated
Fisher's exact test, p=0.0092
Original publication
Acute activation of rat dorsal root ganglion neurons and their satellite glial cells by the serum of patients suffering from fibromyalgia. Clin Exp Rheumatol. Published 22 May 2025. doi:10.
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