Rheumatoid arthritis

Active hand inflammation. Differing clinical and ultrasound patterns in patients with rheumatoid arthritis and psoriatic arthritis – A cross-sectional, multicenter study

Joint Bone SpinePublished Cross-sectional study

Authors' conclusion

Synovial pannus was characteristic of RA, while paratenonitis was more common in PsA. SH≥2+PD correlated with erosive disease

Study context

Population
Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) patients with active hand inflammation; Ultrasound (US) of wrists and MCP joints focusing on extensor and flexor tendons192 (61.7%) women
Participants
292 participants
Exposure
Seropositive RA vs seronegative RA vs PsA with active hand inflammation
  • Seropositive RAn = 91
  • Seronegative RAn = 79
  • PsAn = 122
Outcome
Synovial hypertrophy (SH)≥2+PD
Methodological detailsmulticentre
  • Multicentre

Main finding

As reported in the abstract

P ≤ 0.001

Synovial hypertrophy (SH)≥2+PD overall
144 (49.3%)

Observational data: associations, not effects.

Further findings

Extensor paratenonitis — PsA vs Seropositive RA and seronegative RA

P ≤ 0.01

Factors associated with SH≥2+PD

Erosive disease, OR [3.9-18], P≤0.001
8.4
US global score, OR [1-1.1], P≤0.001
1.1

Factors associated with paratenonitis

Number of swollen joints, OR [1-1.2], P≤0.001
1.1
Joint ankylosis, OR [1.1-16.9], P≤0.05
4.3

Original publication

Active hand inflammation. Differing clinical and ultrasound patterns in patients with rheumatoid arthritis and psoriatic arthritis – A cross-sectional, multicenter study. Joint Bone Spine. Published 30 April 2025. doi:10.1016/j.jbspin.2025.105916

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