Validation study of the Society of Rheumatology (SER)/SEPAR screening criteria for interstitial lung disease in early rheumatoid arthritis patients
Authors' conclusion
The SER/SEPAR criteria for ILD screening demonstrated high sensitivity in recent-onset RA patients, supporting their utility as a tool for early detection in this scenario.
Study context
- Population
- Early rheumatoid arthritis (RA) patients screened for interstitial lung disease (ILD) at diagnosis28 developed ILD
- Participants
- 146 patients
- Outcome
- Sensitivity and specificity of the SER/SEPAR screening criteria for ILD
- Follow-up
- At diagnosis
Methodological detailscross-sectional, retrospective
- Cross-sectional
- Retrospective
Performance
As reported in the abstract
Diagnostic performance of SER/SEPAR criteria for ILD
| Test or model | Sensitivity | Specificity | LR+ | LR- | PPV | NPV | Diagnostic accuracy |
|---|---|---|---|---|---|---|---|
| SER/SEPAR criteria | 92.9 % (95 % CI: 76.5-99.1) | 45.8 % (95 % CI: 36.6-55.2) | 1.71 (95 % CI: 1.41-2.08) | 0.16 (95 % CI: 0.04-0.60) | 28.9 % (95 % CI: 25.1-33.1) | 96.4 % (95 % CI: 87.5-99.1) | 54.8 % (95 % CI: 46.4-63.1) |
SER/SEPAR criteria
Sensitivity92.9 % (95 % CI: 76.5-99.1)
Specificity45.8 % (95 % CI: 36.6-55.2)
LR+1.71 (95 % CI: 1.41-2.08)
LR-0.16 (95 % CI: 0.04-0.60)
PPV28.9 % (95 % CI: 25.1-33.1)
NPV96.4 % (95 % CI: 87.5-99.1)
Diagnostic accuracy54.8 % (95 % CI: 46.4-63.1)
Further findings
ILD by criteria status at diagnosis
- Met criteria: 90 (61.6 %); ILD confirmed
- 26 (28.9 %)
- Did not meet criteria: 56 (38.4 %); ILD identified
- 2 (3.5 %)
ILD prevalence and timing
- Developed ILD, all confirmed by high-resolution computed tomography (HRCT)
- 28 (19.2 %)
- Clinically evident ILD preceding or coinciding with joint symptoms
- 12 (43 %)
- Identified after applying screening protocol
- 16 (57 %)
Original publication
Validation study of the SER/SEPAR screening criteria for interstitial lung disease in early rheumatoid arthritis patients. Semin Arthritis Rheum. Published 30 April 2025. doi:10.
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