A systematic review of the sex differences in risk factors for knee osteoarthritis
Study context
- Population
- Studies reporting sex-specific risk estimates for risk factors for knee OA (MEDLINE, EMBASE, Web of Science)27 studies
- Comparison
- Women vs men: sex-specific associations of risk factors with knee OA
- Outcome
- Sex differences in the association between risk factors and knee OA and their prevalence
Methodological detailsNOS quality assessment (adapted), Quality assessed independently by two researchers using an adapted NOS, converted to three quality categories
- NOS quality assessment (adapted)
- Quality assessed independently by two researchers using an adapted NOS, converted to three quality categories
Pooled result
As reported in the abstract
Sex differences in risk factors for knee OA
- Indication of higher knee OA risk in women with high BMI, alcohol consumption, atherosclerosis and high vitamin E levels
- Indication of higher knee OA risk in men with high physical activity, soft drink consumption and abdominal obesity
- Knee injury, high blood pressure and low step rate seem to affect both women and men
Further pooled results
Study quality (NOS)
- Longitudinal cohort studies (one nested case-control)
- 22
- Longitudinal studies of good quality
- 12
- Longitudinal studies of fair quality
- 10
- Cross-sectional studies
- 5
- Cross-sectional studies of good / fair / poor quality
- 1 / 3 / 1
Original publication
A systematic review of the sex differences in risk factors for knee osteoarthritis. Rheumatology (Oxford). Published 10 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →