Sjögren's disease & overlap diseases
A Stratification Approach Based on Salivary Gland Ultrasonography for Assessing Secretory Function in Sjögren Disease
Authors' conclusion
The novel ultrasonographic scoring model incorporates precise definitions for each stage of SG hypofunction, providing a robust and clinically significant approach to stratification of SG secretory hypofunction in SjD.
Study context
- Population
- Patients with Sjögren disease (SjD); SG secretory hypofunction assessed by whole salivary flows164 derivation, 107 validation
- Participants
- 271 patients
- Outcome
- Ultrasonographic scoring model for staging SG hypofunction
Methodological detailsderivation cohort (1-centre), validation cohort (double-centre)
- Derivation cohort (1-centre)
- Validation cohort (double-centre)
Performance
As reported in the abstract
Discrimination of SG hypofunction vs normal function, and SG hypofunction incidence by stage of the US scoring model
- Both US scores (gland score and OMERACT score) discriminated SjD with hypofunction from normal function
- AUC > 0.8 for both; P < 0.001
- SG hypofunction incidence, initial stage (all 271 patients)
- 18%
- SG hypofunction incidence, progressive stage
- 58%
- SG hypofunction incidence, end stage
- 100%
- Difference in SG hypofunction incidence across stages
- P < 0.01
Further findings
Incidence of SG hypofunction by stage (all 271 patients)
- Initial stage
- 18%
- Progressive stage
- 58%
- End stage
- 100%
- Across stages
- P < 0.01
Lacrimal gland involvement and hyperglobulinaemia (IgG > 16 IU/mL)
- Significantly lower in initial-stage patients vs other stages
- all P < 0.01
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Stratification Approach Based on Salivary Gland Ultrasonography for Assessing Secretory Function in Sjögren Disease. J Rheumatol. Published 1 November 2024. doi:10.
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