Sjögren's disease & overlap diseases
Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren's disease
Authors' conclusion
Primary EBV infection can promote anti-Ro60/anti-Ro52 and anti-U1RNP responses, though by different mechanisms. Some healthy individuals produce anti-SmB' peptide autoantibodies independently of a response to EBNA1.
Study context
- Population
- Previously healthy patient with primary Epstein-Barr virus (EBV) infection who developed SjD with anti-Ro/La and anti-Sm/U1RNP autoantibodies; healthy and disease controls
- Outcome
- Autoantibody responses (anti-Ro60/anti-Ro52, anti-EBNA1, anti-U1RNP) after primary EBV infection in patient 1
Methodological detailscase study with healthy and disease controls
- Case study with healthy and disease controls
Main finding
As reported in the abstract
- Anti-Ro52 and anti-Ro60 autoantibodies present 7 days after primary infection, with IgM to IgG switching
- More than 7 months after primary infection, new and increasing antibodies against EBNA1 and U1RNP appeared concomitantly
- These antibodies bound homologous peptide sequences shared by EBNA1, SmB' and U1-C (U1RNP), consistent with molecular mimicry
- Anti-Ro60/anti-Ro52 production stimulated by acute EBV infection long before onset of anti-EBNA1
Original publication
Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren's disease. Ann Rheum Dis. Published 29 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →