Rheumatoid arthritis

A predictive model for progression to clinical arthritis in at-risk individuals with arthralgia based on lymphocyte subsets and ACPA

Rheumatology (Oxford)Published Prognostic cohort study

Authors' conclusion

We propose a predictive model based on baseline levels of lymphocyte subpopulations and ACPA to identify individuals with arthralgia with the highest risk of progression to clinical arthritis.

Study context

Population
At-risk individuals with arthralgias and either ACPA positivity or meeting the EULAR definition for clinically suspect arthralgia153 in predictive models
Participants
207 individuals
Outcome
Progression to clinical arthritis
Methodological detailslogistic regression model, classification decision tree, Lymphocyte subsets by flow cytometry; anti-CCP by ELISA
  • Logistic regression model
  • Classification decision tree
  • Lymphocyte subsets by flow cytometry; anti-CCP by ELISA

Performance

As reported in the abstract

Predictors of progression to arthritis

Progressed to arthritis

41

Original publication

A predictive model for progression to clinical arthritis in at-risk individuals with arthralgia based on lymphocyte subsets and ACPA. Rheumatology (Oxford). Published 9 August 2024. doi:10.1093/rheumatology/keae383

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