Fine Particulate Matter Components and Risk of Rheumatoid Arthritis: A Large General Canadian Open Cohort Study
Authors' conclusion
Exposure to PM2.5 components was modestly associated with RA risk.
Study context
- Population
- Canadian adults, Ontario administrative health data, January 2007 to December 2019
- Participants
- 11,696,930 adults130,934,256 person-years
- Exposure
- Per-decile increase in exposure to seven PM2.5 components (mixture) and per 1 μg/m³ increase in overall PM2.5
- Outcome
- Time to incident RA onset (physician billing and hospitalization discharge diagnostic codes)
Methodological detailspopulation-based, administrative health data, quantile g-computation, Cox proportional hazard models
- Population-based
- Administrative health data
- Quantile g-computation
- Cox proportional hazard models
Main finding
As reported in the abstract
Incident RA (67,676 new cases)
aHR per decile increase in all seven PM2.5 components (mixture)
1.027
95% CI 1.021–1.033
aHR per 1 μg/m³ increase in overall PM2.5
1.023
95% CI 1.017–1.029
Observational data: associations, not effects.
Original publication
Fine Particulate Matter Components and Risk of Rheumatoid Arthritis: A Large General Canadian Open Cohort Study. Arthritis Care Res (Hoboken). Published 9 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →