A cohort study on the associations between age at natural menopause and rheumatoid arthritis in postmenopausal women from the Canadian Longitudinal Study on Aging
Main finding · Incident RA, ANM ≥50 with hormone replacement therapy ≥8 years vs ANM ≤44 never-usersResult — go to the resultAdjusted hazard ratio 0.2 95% CI 0.1–0.7Authors' conclusion
Our findings suggest a potential beneficial effect of longer estrogen exposure on the risk of developing rheumatoid arthritis.
Study context
- Population
- Naturally postmenopausal women aged 45–85 years from the Canadian Longitudinal Study on Aging without RA prior to menopause
- Exposure
- Age at natural menopause ≥50 or 45-49 vs ≤44 years
- Outcome
- Incidence of RA
- Follow-up
- 10-year period
Methodological details10-year follow-up, survival analysis, unadjusted and adjusted multivariable Cox regression
- 10-year follow-up
- Survival analysis
- Unadjusted and adjusted multivariable Cox regression
Main finding
As reported in the abstract
Incident RA, ANM ≥50 with hormone replacement therapy ≥8 years vs ANM ≤44 never-users
Adjusted hazard ratio
0.2
95% CI 0.1–0.7
ANM ≥50vs ANM ≤ 44
aHR 0.2 (95% CI 0.1–0.7)
Observational data: associations, not effects.
Original publication
A cohort study on the associations between age at natural menopause and rheumatoid arthritis in postmenopausal women from the Canadian Longitudinal Study on Aging. Semin Arthritis Rheum. Published 2 May 2025. doi:10.
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