Perceived Stress and Prediction of Worse Patient‐Reported Outcomes in a Rheumatoid Arthritis Cohort
Authors' conclusion
Among a longitudinal RA cohort, those with greater perceived stress had worse pain, greater fatigue, and lower physical function at follow-up.
Study context
- Population
- Participants in a longitudinal rheumatoid arthritis (RA) cohort with assessments every six months (88% female; mean ± SD age 58 ± 13 years)
- Participants
- 133 participants
- Exposure
- Perceived stress and subsequent RA outcomes
- Outcome
- Patient-reported disease activity (RA Disease Activity Index), pain (PROMIS Pain Interference), fatigue (PROMIS Fatigue) and physical function (PROMIS Physical Function) at the subsequent time point
- Follow-up
- Subsequent visits over 18 months
Methodological detailslongitudinal, time-lagged linear mixed effects models, adjusted for potential confounders
- Longitudinal
- Time-lagged linear mixed effects models
- Adjusted for potential confounders
Main finding
As reported in the abstract
Association of stress with outcomes at the subsequent time point:
- Adjusted
- Time-lagged
Greater self-reported disease activity: β
0.11
95% CI 0.03–0.19
More pain: β
0.61
95% CI 0.29–0.94
More fatigue: β
0.71
95% CI 0.32–1.11
Lower physical function: β
−0.33
95% CI −0.59 to −0.06
Observational data: associations, not effects.
Original publication
Perceived Stress and Prediction of Worse Patient‐Reported Outcomes in a Rheumatoid Arthritis Cohort. Arthritis Care Res (Hoboken). Published 2 May 2025. doi:10.
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