Lupus & antiphospholipid syndrome
2023 American College of Rheumatology (ACR)/EULAR antiphospholipid syndrome classification criteria
Authors' conclusion
These new ACR/EULAR APS classification criteria were developed using rigorous methodology with multidisciplinary international input.
Study context
- Population
- Validation cohort; independent adjudicators' consensus as gold standard
- Comparison
- 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria vs 2006 revised Sapporo classification criteria
- Outcome
- Specificity and sensitivity for APS classification vs adjudicators' consensus
Methodological detailsinternational, multidisciplinary, modified Delphi, nominal group technique, multicriteria decision analysis, validation cohort, Phase I: criteria generation by surveys and literature review, Phase II: criteria reduction by modified Delphi and nominal group technique, Phase III: criteria definition, reduction with real-world patient scenarios, weighting via consensus-based multicriteria decision analysis, threshold identification, Phase IV: validation using independent adjudicators' consensus as gold standard
- International
- Multidisciplinary
- Modified Delphi
- Nominal group technique
- Multicriteria decision analysis
- Validation cohort
- Phase I: criteria generation by surveys and literature review
- Phase II: criteria reduction by modified Delphi and nominal group technique
- Phase III: criteria definition, reduction with real-world patient scenarios, weighting via consensus-based multicriteria decision analysis, threshold identification
- Phase IV: validation using independent adjudicators' consensus as gold standard
Performance
As reported in the abstract
Classification performance in the validation cohort
| Test or model | Sensitivity | Specificity |
|---|---|---|
| 2023 ACR/EULAR APS criteria | 84% | 99% |
| 2006 revised Sapporo criteria | 99% | 86% |
Sensitivity
2023 ACR/EULAR APS criteria84%
2006 revised Sapporo criteria99%
Specificity
2023 ACR/EULAR APS criteria99%
2006 revised Sapporo criteria86%
Original publication
2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis. Published 28 August 2023. doi:10.
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