Lupus & antiphospholipid syndrome
Adherence patterns to medications and their association with subsequent hospitalization in adult Egyptian patients with systemic lupus erythematosus
Authors' conclusion
Egyptian SLE patients have an alarmingly high percentage of medication non-adherence. There is a strong association between medication non-adherence and frequency of hospitalization and cumulative clinical manifestations.
Study context
- Population
- Adult Egyptian patients with systemic lupus erythematosus (SLE) prescribed oral medications, rheumatology outpatient clinic, Egypt129 females · 32 males
- Participants
- 161 patients
- Exposure
- Non-adherent vs adherent
- Non-adherentn = 93
- Adherentn = 68reference
- Outcome
- Medication adherence pattern (CQR) and association of non-adherence with hospitalization
Methodological detailsinterview-based, single outpatient clinic
- Interview-based
- Single outpatient clinic
Main finding
As reported in the abstract
Medication adherence (CQR) and hospitalization
Non-adherent
93
events
Adherent
68
events
P < 0.001
Observational data: associations, not effects.
Further findings
Antimalarial use
P = 0.039
Recurrent fever
P = 0.042
Lymphadenopathy
P = 0.004
Recurring oral ulcers
P = 0.001
- Substantial hair loss
- P = 0.009
- Yearly outpatient visits
- P = 0.007
Substantial hair loss
- Reported as 87.1% vs 98.5%, lower in adherents
Yearly outpatient visits
- Considerably greater in adherents
Beliefs: medicines disrupt daily routine; fear of adverse drug reaction
- Non-adherents believed medicines disrupt daily routine
- P < 0.001
- Non-adherents more afraid of adverse drug reaction
- P < 0.001
Sociodemographics differing between groups
- Marital status
- P = 0.009
- Employment
- P = 0.032
- Frequency of physical activity
- P = 0.045
Original publication
Adherence patterns to medications and their association with subsequent hospitalization in adult Egyptian patients with systemic lupus erythematosus. Lupus. Published 26 August 2023. doi:10.
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