What to Expect When Systemic Treatment in Juvenile Idiopathic Arthritis Is Withdrawn?
Authors' conclusion
Flares are frequent when systemic treatment is withdrawn, and uveitis or joint injections could be related risk factors.
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA) who had received systemic treatment and withdrawn it on at least 1 occasion185 withdrew treatment
- Participants
- 404 patients
- Exposure
- Remission survival after systemic treatment withdrawal, by treatment received (MTX alone or with bDMARDs) and JIA subgroup
- Outcome
- Remission survival after systemic treatment withdrawal
Methodological detailsKaplan-Meier analysis, multivariate analysis
- Kaplan-Meier analysis
- Multivariate analysis
Main finding
As reported in the abstract
Flare after systemic treatment withdrawal
Patients who flared
110
59%
Median time to flare
2.3 years
Observational data: associations, not effects.
Further findings
Flare by drug withdrawn in patients on MTX + bDMARDs
- MTX alone withdrawn: flared
- 29%
- MTX alone withdrawn: median time to flare
- 6.3 years
- Only bDMARD withdrawn: flared
- 57%
- Only bDMARD withdrawn: median time to flare
- 1.1 years
Original publication
What to Expect When Systemic Treatment in Juvenile Idiopathic Arthritis Is Withdrawn? J Rheumatol. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →