“What Came First?” Population‐Based Evaluation of Health Care Encounters for Depression and Anxiety Before and After Inflammatory Arthritis Diagnosis: Disentangling the Relationship Between Mental Health and Arthritis
Authors' conclusion
Findings suggest a role for depression and anxiety in characterizing the IA prodrome period and generate hypotheses regarding overlapping biopsychosocial processes that link IA and mental health comorbidities.
Study context
- Population
- Individuals (≥18 years) with incident inflammatory arthritis (IA) and IA-free controls, British Columbia, Canada, January 1, 2001–March 31, 2018matched cohort
- Participants
- 80,238 vs 80,238
- Exposure
- Incident inflammatory arthritis vs IA-free controls matched on age and sex
- IAn = 80,238
- IA-free controlsn = 80,238reference
- Outcome
- Depression and anxiety health care encounters and use of antidepressants or anxiolytics in each yearly interval five years before and after IA diagnosis
- Follow-up
- Each yearly interval five years before and after IA diagnosis
Methodological detailslinked administrative health data, matched on age and sex, multivariable logistic regression
- Linked administrative health data
- Matched on age and sex
- Multivariable logistic regression
Main finding
As reported in the abstract
Depression and anxiety health care use, yearly intervals before and after diagnosis
IA vs IA-free controlsAdjusted odds ratio (95% CI)
One or more depression visits, year immediately before diagnosis
1.61(1.55–1.66)
One or more anxiolytics, year immediately before diagnosis
1.71(1.66–1.77)
One or more antidepressants, year immediately after diagnosis
1.95(1.89–2.00)
Observational data: associations, not effects.
Original publication
“What Came First?” Population‐Based Evaluation of Health Care Encounters for Depression and Anxiety Before and After Inflammatory Arthritis Diagnosis: Disentangling the Relationship Between Mental Health and Arthritis. Arthritis Care Res (Hoboken). Published 29 February 2024. doi:10.
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