Lupus & antiphospholipid syndrome
Vascular liver disorders in patients with antiphospholipid syndrome: a national retrospective multicentre study
Authors' conclusion
Although rare, VLD may be the presenting manifestation of APS. APS patients with VLD are at high risk of both recurrent thrombotic events and major bleeding.
Study context
- Population
- Antiphospholipid syndrome (APS) patients with vascular liver disorders (portal vein thrombosis (PVT), Budd-Chiari syndrome (BCS), porto-sinusoidal vascular disorder (PSVD)) followed in four French tertiary university centres41 vascular liver disorders (VLD)
- Participants
- 34 patients
- Outcome
- Clinical, serological and liver characteristics at diagnosis of APS patients with VLD
Methodological detailsnational, multicentre
- National
- Multicentre
Main finding
As reported in the abstract
Clinical features of APS patients with VLD
- Women
- 59%
- Mean age, years
- 35+/−15
- Primary APS
- 65%
- PVT
- n = 26/41, 63%
- BCS
- n = 12/41, 29%
- PSVD
- n = 3/41, 7%
- VLD as first thrombotic event
- 79% (n = 27/34)
- Portal hypertension
- 15/34, 44%
- Esophageal varices at VLD diagnosis
- 10/34, 29%
- Treated with oral anticoagulants, VKA in all but one case
- all patients
Observational data: associations, not effects.
Further findings
New thrombotic event during follow-up · median 9.5 (5; 14) years
- New thrombotic event
- 62% (n = 21/34)
Safety
Major bleeding during follow-up · median 9.5 (5; 14) years
- Major bleeding
- 26% (n = 9/34)
Original publication
Vascular liver disorders in patients with antiphospholipid syndrome: a national retrospective multicentre study. Rheumatology (Oxford). Published 9 April 2025. doi:10.
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