Lupus & antiphospholipid syndrome

Bacterial infection in patients with juvenile systemic lupus erythematosus and fever

Pediatr Rheumatol Online JPublished Case-control study

Authors' conclusion

Bacterial infection was detected in 17% of JSLE patients with fever. Procalcitonin > 0.9 ng/mL is a critical marker for identifying bacterial infection.

Study context

Population
Patients with juvenile SLE presenting with fever
Participants
116 patients
Outcome
Factors associated with bacterial infection

Main finding

As reported in the abstract

Bacterial infection
Bacterial infection identified
17%
Procalcitonin (PCT) > 0.9 ng/mL retained significance in adjusted model
p < 0.01
Nagelkerke's R2
0.65

Observational data: associations, not effects.

Original publication

Bacterial infection in patients with juvenile systemic lupus erythematosus and fever. Pediatr Rheumatol Online J. Published 8 April 2025. doi:10.1186/s12969-025-01088-1

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