Lupus & antiphospholipid syndrome
Validation of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) in Brazilian SLE patients
Authors' conclusion
The present study demonstrated that the SLE-DAS Pt-BR is valid and capable of measuring SLE disease activity.
Study context
- Population
- Patients ≥18 years old meeting classification criteria for SLE, Brazil (Brazilian-Portuguese SLE-DAS version)mean age 44.5 years
- Participants
- 365 patients
- Outcome
- Measurement properties of SLE-DAS Pt-BR: reliability (ICC2.1, SEM, MDD), construct validity vs SLEDAI-2K, PGA, DORIS and LLDAS, and performance vs PGA
Methodological detailstest-retest, multicentre
- Test-retest
- Multicentre
Main finding
As reported in the abstract
- Intra-rater reliability, ICC2.1
- 0.999
- Inter-rater reliability, ICC2.1
- 0.945
- Correlation with SLEDAI-2K, rho
- 0.895
- Correlation with PGA, rho
- 0.861
- Sensitivity, specificity and accuracy vs PGA for remission and moderate/severe activity
- above 90%
- Sensitivity, specificity and accuracy vs PGA for mild activity
- above 80%
Observational data: associations, not effects.
Further findings
Remission by SLE-DAS Pt-BR
- In remission
- 57.3%
Agreement with SLEDAI-2K categories
- Remission concordance
- 99.5%
- Moderate/severe activity concordance
- 77.9%
- Mild activity concordance
- 42.9%
Agreement with definitions of remission (DORIS) remission and LLDAS
- Most patients in DORIS remission and LLDAS also in remission and low disease activity by SLE-DAS Pt-BR
Original publication
Validation of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) in Brazilian SLE patients. Rheumatology (Oxford). Published 4 July 2025. doi:10.
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