Validation of the ankle-specific pediatric arthritis ultrasound scoring system in children with juvenile idiopathic arthritis
Authors' conclusion
Our findings demonstrate excellent diagnostic accuracy of the PAUSS-ankle in detecting the presence and severity of ankle synovitis when compared to ceMRI.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) undergoing musculoskeletal ultrasound (MSUS) of one or both ankles63 MSUS, 15 contrast-enhanced MRI (ceMRIs)
- Participants
- 32 children
- Comparison
- PAUSS-ankle MSUS vs clinical assessment, with ceMRI as reference
- ceMRIn = 15reference
- Outcome
- Diagnostic accuracy of PAUSS-ankle scores for ankle synovitis vs ceMRI
Methodological detailsprospective, ceMRI (Rheumatoid Arthritis MRI System (RAMRIS)) as reference
- Prospective
- ceMRI (RAMRIS) as reference
Performance
As reported in the abstract
Detection of ankle synovitis vs ceMRI
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| PAUSS-ankle | 0.89 (CI 0.78-1.00) | 79 % | 100 % |
| Clinical assessment | 0.71 (CI: 0.58-0.85) | 57 % | — not stated in the abstract |
AUC
PAUSS-ankle0.89 (CI 0.78-1.00)
Clinical assessment0.71 (CI: 0.58-0.85)
Sensitivity
PAUSS-ankle79 %
Clinical assessment57 %
Specificity
PAUSS-ankle100 %
Clinical assessment— not stated in the abstract
— not stated in the abstract
Further findings
Correlation of PAUSS-ankle total B-mode score with physical examination findings
- Moderate correlation, r
- 0.43, p < 0.001
Correlation of PAUSS-ankle B-mode score with RAMRIS (disease severity, each joint area and whole ankle)
- Significant strong correlations, r
- 0.68-0.90, p < 0.005
Original publication
Validation of the ankle-specific pediatric arthritis ultrasound scoring system in children with juvenile idiopathic arthritis. Semin Arthritis Rheum. Published 1 September 2024. doi:10.
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