The assessment of bone health in children with juvenile idiopathic arthritis; comparison of different imaging-based methods
Authors' conclusion
Categorizing DXA LS and automated radiographic Z-scores on a 0-5 scale gave a weak to moderate agreement between the two methods
Study context
- Population
- Children aged 4–16 years with juvenile idiopathic arthritis (JIA), examined between 2015 and 2020; subjects selected on DXA BMD and BoneXpert BHI to cover the whole rangeselected from 228 children
- Participants
- 120 children
- Comparison
- Automated radiographic BHI (BoneXpert) vs DXA BMD; cone-beam CT inter-observer agreement
- Outcome
- Agreement between BHI and DXA BMD
Methodological detailsmulticentre, method comparison
- Multicentre
- Method comparison
Performance
As reported in the abstract
- Correlation of absolute BHI and BMD, total body less head (TBLH)
- r = 0.75, p < 0.001
- Correlation of absolute BHI and BMD, lumbar spine (L1-L4)
- r = 0.77, p < 0.001
- Correlation of BHI standard deviation score (SDS) and BMD TBLH Z-scores (weak but significant)
- r = 0.34
- Range of this correlation between the three study sites
- r = 0.31 to r = 0.42
- Agreement of BHI SDS and DXA BMD Z-scores categorised 0-5, TBLH and LS (weak)
- w-kappa of 0.2
- Same agreement with quadratic weights
- 0.3
- Agreement at one of three study sites, particularly spine (moderate)
- kappa 0.4 - 0.5
Further findings
Cone-beam CT inter-observer agreement, left TMJ (1-3 scale)
- First observer: score 1 / score 2, of 94 left TMJs
- 59 / 31
- Second observer: score 1 / score 2
- 87 / 7
- Inter-observer agreement (poor)
- kappa 0.1
Original publication
The assessment of bone health in children with juvenile idiopathic arthritis; comparison of different imaging-based methods. Pediatr Rheumatol Online J. Published 29 August 2024. doi:10.
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